Free Radical Scavengers Antioxidants

In the case of efforts to interrupt reactive oxygen damage, the polyethylene conjugated form of the superoxide radical scavenger Cu/Zn superoxide dismutase (PEG-SOD) was evaluated in trials conducted in moderate and severe TBI patients. Although it showed a positive trend in an initial small phase II trial,18 subsequent phase III trials failed to show any enhancement of neurological recovery.19 A larger development program was undertaken with the 21-aminosteroid LP inhibitor tirilazad (U-74006F; 'lazaroid'; Figure 2). Tirilazad was extensively evaluated in animal models of SCI, TBI, ischemic stroke, and SAH, and shown to exert a variety of neuro- and vasoprotective effects.20,21 Based on these preclinical studies, clinical trials of tirilazad were conducted in TBI, SAH, ischemic stroke,

Your Heart and Nutrition

Your Heart and Nutrition

Prevention is better than a cure. Learn how to cherish your heart by taking the necessary means to keep it pumping healthily and steadily through your life.

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