Free Radical Scavengers Antioxidants

In the case of efforts to interrupt reactive oxygen damage, the polyethylene conjugated form of the superoxide radical scavenger Cu/Zn superoxide dismutase (PEG-SOD) was evaluated in trials conducted in moderate and severe TBI patients. Although it showed a positive trend in an initial small phase II trial,18 subsequent phase III trials failed to show any enhancement of neurological recovery.19 A larger development program was undertaken with the 21-aminosteroid LP inhibitor tirilazad (U-74006F; 'lazaroid'; Figure 2). Tirilazad was extensively evaluated in animal models of SCI, TBI, ischemic stroke, and SAH, and shown to exert a variety of neuro- and vasoprotective effects.20,21 Based on these preclinical studies, clinical trials of tirilazad were conducted in TBI, SAH, ischemic stroke,

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Your Heart and Nutrition

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