Glitinides nonsulfonylurea secretagogues

Glitinides, like sulfonylureas, act at the K+-ATP channels to augment glucose-stimulated insulin secretion. Glitinides differ from sulfonylureas by having a more rapid onset and shorter duration of action, primarily lowering postprandial glucose levels. They are only effective in individuals with viable pancreatic b-cells and are therefore not suitable for individuals with T1DM. Repaglinide and nateglinide (Figure 7) are the two glitinides approved by the FDA for use in the USA.

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