Figure 7 Chemical structure of BN 80933, a dual inhibitor of lipid peroxidation and neuronal nitric oxide synthase (nNOS).58 The peroxidation-inhibiting chroman moiety works by donating an electron from the hydroxyl group to a lipid peroxyl radical.

with a moiety that will either inhibit 'NO production or scavenger peroxynitrite or peroxynitrite-derived radicals. Two examples of this approach are the 2-methylaminochroman U-78517F57 (Figure 2) and BN-8093358 (Figure 7). These new compound entities link the peroxyl radical scavenging chroman ring structure of vitamin E (Figure 2) via a piperazine bridge to the peroxyl radical scavenging amine moiety of tirilazad in the case of U-78517F, or with the an inhibitor nitric oxide synthase (NOS) in the case of BN-80933, which would decrease production of 'NO and consequently reduce peroxynitrite formation. U-78517F is more effective than either vitamin E or the vitamin E chroman in protecting culture spinal cord neurons from oxidative damage.57 Similarly, BN-80933 has greater neuroprotective activity than other single antioxidant mechanism new compound entities in rodent stroke and TBI models than either the trolox or NOS-inhibiting moieties alone.58

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment