20d R5=cyclo-C3H5: IC50=2.2 |M 21d

R3,R4=Cl: IC50=0.03 |M R3,R4=Br: IC50=0.03 |M R3=Ph, R4=CO2Et: IC50=0.17 |M R3=Ph, R4=CONHPh: IC50=0.007 |M

Figure 9 Structures of key compounds and structure-activity relationships leading to the discovery of atorvastatin.

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