H3c

12 Clofibrate 13 Gemfibrozil 14 Fenofibrate

W CO2H CO2H N

15 Ciprofibrate 16 Bezafibrate 17 Niacin

Figure 8 Structures of approved fibrates and niacin as HDLc-elevating agents.

is complex and includes activation of peroxisome proliferator-activated receptor (PPAR), a family of nuclear receptors (PPAR-a, PPAR-b/S, PPAR-g) that act as transcription factors and control genes involved in both lipid and lipoprotein metabolism as well as glucose homeostasis. Fibrates are selective PPAR-a agonists.56 Niacin 17 is currently the best available therapy for raising HDLc, attaining increases of 30% or more.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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