Figure 8 Chemical structures of compounds under clinical investigation as potential medications for the treatment of drug addiction.

achieve abstinence or delaying relapse,55 although this negative result might have been due to poor compliance.57 This drug interferes with alcohol metabolism by inhibiting alcohol dehydrogenase, leading to an accumulation of acetaldehyde, making the patient feel quite ill. According to the drug monograph for disulfiram:

Symptoms of the disulfiram-alcohol reaction include flushing, throbbing in the head and neck, throbbing headache, dypsnea, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, hyperventilation, tachycardia,





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