Hemorrhagic Stroke Models

As noted above, the two basic types of hemorrhagic strokes are the intracerebral hemorrhage and the SAH. For the former the approach is simply to inject a volume of the animal's own blood directly into the brain parenchyma, and then to analyze the volume of damage to the surrounding brain tissue. With regard to the latter, most of the available models involve the injection of a volume of the autologous blood, withdrawn immediately prior to SAH induction from the systemic circulation of the animal (e.g., rat, cat, rabbit, and dog), into the subarachnoid space via injection into the cisterna magna, or over one of the cerebral hemispheres via a small burr hole and puncture of the dura mater covering the brain. The most common endpoints for new compound entity evaluation involve measurement of blood-brain barrier compromise or decreases in cerebral blood flow during the first several post-SAH hours, or the assessment of cerebral vasospasm by histological or arteriographic methods between 2 and 7 days. The most sophisticated SAH model available involves the neurosurgical placement of an autologous blood clot around the base of the middle cerebral artery in monkeys, followed by measurement of arteriographic and histological ischemic damage at 7 days. However, the cost of evaluating a single-dose level of new compound entity for its ability to inhibit delayed cerebral vasospasm in that model runs into the hundreds of thousands of dollars.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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