High Density Lipoprotein Cholesterol Elevating Agents

In CHD patients at risk because of low HDLc, it is still unclear to what extent HDLc must be raised to produce a cardiovascular benefit, but elevations of 50% or more may be required.16 Current therapies offer only modest improvements and are often limited by side effects.16,56 A clear need exists to identify safer and more effective HDLc-raising drugs for use as monotherapy or in conjunction with other lipid-lowering agents. Several new strategies are under investigation that might lead to more pronounced HDLc elevations.16,85 These include targeting enzymes associated with lipoprotein metabolism (e.g., hepatic triglyceride lipase, LpL, LCAT, or PLTP), modulating SR-B1 and h3co och3

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