Hyperplasia Prostate Dysfunction

M G Wyllie and S Phillips, Urodoc Ltd, Herne Bay, UK

© 2007 Published by Elsevier Ltd.

6.24.1 Introduction to the Prostate 551

6.24.1.1 The Aging Prostate 552

6.24.2 The Definition of Benign Prostatic Hyperplasia 554

6.24.3 The Pathophysiology of Benign Prostatic Hyperplasia 555

6.24.3.1 Genetics 555

6.24.3.2 Cellular Changes 556

6.24.3.3 Changes in Proliferation, Apoptosis, and Senescence 556

6.24.3.4 Remodeling 557

6.24.3.5 Androgen-Related Changes 558

6.24.3.6 Inflammation 559

6.24.3.7 Impact on Bladder Pathophysiology 559

6.24.3.8 Impact on Lower Urinary Tract Symptoms 560

6.24.4 The Diagnosis of Benign Prostatic Hyperplasia 560

6.24.5 Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms 562 6.24.5.1 Lower Urinary Tract Symptoms and Sexual Dysfunction 562

6.24.6 Benign Prostatic Hyperplasia and Renal Disease 563

6.24.7 Treatment Targets for Benign Prostatic Hyperplasia 563

6.24.7.1 Receptor Targets 563

6.24.7.2 Pharmacotherapy 564

6.24.7.2.1 a^Adrenoceptor antagonists 564

6.24.7.2.2 5a-Reductase inhibitors 565

6.24.7.2.3 Side effects 565

6.24.8 Management Approaches 566 6.24.8.1 New Avenues 568

6.24.9 Treatment Complications and Progression 568

6.24.10 Other Causes of Incontinence 568

6.24.10.1 Prostate Surgery and Incontinence 569

6.24.10.2 Prostatitis 570

6.24.10.3 Other Prostatitic Conditions Causing Incontinence 571 References 571

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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