In Vitro Models

Since epilepsy is a disorder associated with the sudden synchronous and repetitive firing of neurons, in vitro electrophysiological studies are especially useful and can be conducted in both normal and transfected cell lines, transfected oocytes, and brain slices to study the effects of NCEs on nerve conduction parameters and induced-seizure-like activity.19,20 Generalized tonic-clonic seizures can be induced in animals by the periodic application of subconvulsive seizures9 or by using alumina gel, zinc, cobalt, or Fe3 + implantation in the brain.26 This leads to epileptiform activity in the whole animal and can be studied in ex vivo electrophysiological slice preparations that can be challenged with application of NCEs.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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