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Figure 8 The structure of three insulin analogs. The human insulin molecule, derived from its proinsulin precursor, consists of an A chain and a B chain. The insulin lispro molecule has a proline residue at position B28 that has been transposed with the lysine residue at position B29 of the B chain of the human insulin molecule. Insulin aspart has a B28 amino acid proline substitution with aspartic acid. In the insulin glargine molecule, glycine has replaced the asparagine residue at position A21 and two arginine residues have been added to the carboxyl terminus of the B chain. (Reprinted from Hirsch, I. B. N. Engl. J. Med. 2005, 352, 174-183. Copyright © 2006 Massachusetts Medical Society. All rights reserved.)

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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