At present, there is a 'trend' toward using combination therapies to target BPH and comorbid conditions such as erectile dysfunction, which has important consequences for safety considerations. In a recent placebo-controlled study of healthy volunteers, the combination of tadalafil (a phosphodiesterase type 5 (PDE5)-inhibitor used in the treatment of erectile dysfunction) with doxazosin significantly reduced the blood pressure compared with tadalafil and placebo (the mean difference in systolic blood pressure was 9.8 mmHg); however, this effect was not observed with tadalafil and tamsulosin, supporting the conservative use of this latter combination in the treatment of BPH patients with erectile dysfunction.50 Whether, the PDE5-inhibitor can prevent the high incidence of abnormal ejaculation observed with tamsulosin remains a key topic for future studies assessing combination therapies. However, combination strategies have now become recommended as treatment approaches in guidelines (as discussed below).

Naturally Cure Erectile Dysfunction

Naturally Cure Erectile Dysfunction

Whether we like it or not, for many men it gets increasingly difficult to perform sexually as the years advance.

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