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Figure 2 Serum concentration profiles of testosterone (T), BT, DHT, and 17|3-estradiol (E2) during and after the nighttime application of two testosterone transdermal systems (TTDs) to the back of 34 hypogonadal men (mean+SD). The shaded areas represent 95% confidence intervals for morning hormone levels in normal men between the ages of 20 and 65 years. The arrow denotes the 24-h duration of TTD application.50 (Reproduced with permission from Meikle, A. W.; Arver, S.; Dobs, A. S.; Sanders, S. W.; Rajaram, L.; Mazer, N. A. J. Clin. Endocrinol. Metab. 1996, 81, 1832-1840. Copyright 1996, The Endocrine Society.)

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