Tegaserod (9) is another 5HT4 partial agonist approved for use in the treatment of C-IBS and chronic constipation. It stimulates colonic propulsion both in vitro28 and in vivo29 and also increases gastric emptying in animal models, including a mouse model of diabetic gastroparesis.30 Tegaserod increases gastric emptying and intestinal transit in both healthy subjects31 and in IBS patients.32 In a model of colonic transit in healthy volunteers, tegaserod reversed the delay in colonic transit induced by dietary modification.33

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Constipation Prescription

Constipation Prescription

Did you ever think feeling angry and irritable could be a symptom of constipation? A horrible fullness and pressing sharp pains against the bladders can’t help but affect your mood. Sometimes you just want everyone to leave you alone and sleep to escape the pain. It is virtually impossible to be constipated and keep a sunny disposition. Follow the steps in this guide to alleviate constipation and lead a happier healthy life.

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