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Compared to regular insulin, insulins lispro, aspart, and glulisine have more rapid onset, earlier peak effect, and shorter duration of action. Optimally, these analogs are injected immediately prior to or after starting a meal, due to their onset of action within 5-15 min. Regular insulin, with a longer onset of action, is injected 30-60 min prior to a meal, and can be difficult to time accurately. With a pharmacokinetic profile closer to physiologic insulin, the rapid-acting analogs are potentially more effective in lowering postprandial blood glucose levels and reducing risk of hypoglycemia compared to regular insulin.

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