CH2CH2N(CH3)2 Diltiazem

Figure 3 Chemical structures of nondihydropyridine calcium-channel antagonists of first generation.

Table 3 Clinical doses, elimination half-life (t1/2), and oral bioavailability of commonly used formulations of Ca2 + channel antagonists


Clinical dose (mg)

Oral bioavailability (%)

Amlodipine (Norvasc) Verapamil (Isoptin SR) Nifedipine (Adalat CC) Diltiazem (Cardizem SR) Felodipine ER Nicardipine SR Nisoldipine (Sular CC)

120-360 q.d. or b.i.d. 2.5-10 q.d. 60-120 q.d. 20-40 q.d.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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