Info

Verapamil

OCH3

CH2CH2N(CH3)2 Diltiazem

Figure 3 Chemical structures of nondihydropyridine calcium-channel antagonists of first generation.

Table 3 Clinical doses, elimination half-life (t1/2), and oral bioavailability of commonly used formulations of Ca2 + channel antagonists

Drug

Clinical dose (mg)

Oral bioavailability (%)

Amlodipine (Norvasc) Verapamil (Isoptin SR) Nifedipine (Adalat CC) Diltiazem (Cardizem SR) Felodipine ER Nicardipine SR Nisoldipine (Sular CC)

120-360 q.d. or b.i.d. 2.5-10 q.d. 60-120 q.d. 20-40 q.d.

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