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The results are expressed as equilibrium dissociation constants (Kd) in nM, using3 H-imipramine binding to human serotonin transporter, [3H]-nisoxetine binding to human norepinephrine transporter, and 3 H-WIN or [125]RTI-55a binding to human dopamine transporter, or for reboxetine, [3H]-citalopram binding to human serotonin transporter and 3H-nisoxetine binding to the human norepinephrine transporter.

a Data is reproduced and modified with permission from Burger's Medicinal Chemistry and Drug Discovery, 6th ed.: Vol. 6, Nervous System Agents; Abraham, D. J., Ed. J. Wiley & Sons, Inc.: New York, 2003, p 500.39 b Data from Owens, M. J.; Knight, D. L.; Nemeroff, C. B. Biol. Psychiatry 2001, 50, 345-350.40

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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