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DHA Infliximab

Photoreceptor cell membranes are rich in DHA; certain oxidative metabolites may be endogenous neuroprotectants Many existing agents already marketed

Overwhelming oxidative stress may generate electrophilic/ toxic fatty acid degradants

Side effect tolerance for some agents (cf. thalidomide)

Embryonic stem cell implantation92

Dry and wet

Embryonic stem cells

Replacement of dead photoreceptors could restore lost sight

Replacement cells may not have full function; cancer risk?

ACE, angiotensin-converting enzyme; AT2, angiotensin II; DHA, (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahex-aenoic acid; NGF, nerve growth factor; TNF-a, tumor necrosis factor a.

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