Figure 12 Structures of key compounds leading to the discovery of ezetimibe.

Figure 13 Structures of key probucol metabolites.

be taken at any time of day or night. Ezetimibe has no effect on the major drug-metabolizing enzymes and consequently its potential to cause drug-drug interactions is negligible. The molecular target for ezetimibe is the Niemann-Pick C1-Like1 protein that mediates cholesterol absorption within the brush-border membranes of intestinal enterocytes.74 This discovery should facilitate the search for new-generation cholesterol absorption inhibitors. Ezetimibe 10 was approved in 2002 in the US as monotherapy, and in 2004 as a fixed combination with simvastatin, known as Vytorin.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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