Disease Basis


Stimuli that can evoke an emetic response are many and varied. As noted, these include but are not limited to: pharmacologically active therapeutic agents such as platinum-containing cytostatic drugs, DNA alkylating agents such as cyclophosphamide, and drugs used to treat Parkinson's disease (including l-DOPA, apomorphine (1), and bromocriptine; see 6.08 Neurodegeneration); ionizing radiation; diseases affecting the vestibular apparatus of the middle ear; and environmental factors such as motion and pregnancy. While the range of emetic stimuli is diverse, the pathways of the central nervous system (CNS) through which the emetic response is mediated are surprisingly discrete and largely well described (Figure 1). What is less surprising is that the inputs to these CNS centers are more varied and comprise a number of different neuronal pathways, both peripheral and central, as well as circulatory and systemic routes.

Nausea pathways

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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