Inhibition of Calpain Mediated Proteolytic Damage

As noted earlier in this chapter, disruption of intracellular Ca2 + homeostasis is a critical issue in the secondary neurodegenerative pathophysiology of stroke, TBI, and SCI. Following an injurious event, there is a massive posttraumatic Ca2 + influx, initially caused by depolarization-induced glutamate release and the opening of glutamate receptor-operated and voltage-dependent Ca2 + channels.3,4 Increased intracellular Ca2 + concentrations in TBI models have been demonstrated in each of the mainstream rodent TBI models.5 Excessive intracellular Ca2 +

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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