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The essential role of insulin in the treatment of T1DM is universally accepted, whereas its use in T2DM is often considered the last resort. Insulin should be viewed as a valuable therapeutic tool for early intervention, to attain and maintain target levels of glycemic control.

The evolution of insulin preparations, from those 'purified' from animal pancreases, to human-insulin produced with recombinant DNA technology, and the present use of insulin analogs, represents more than 80 years of collaboration among industry, clinical, and basic research, and millions of people with diabetes.

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