Thrombus formation is a vital part of the hemostatic mechanism. Under normal circumstances formation of the thrombus is limited to the site of vessel injury and is regulated by different mechanisms to prevent further progression. Under pathological conditions, a thrombus can propagate into otherwise normal vessels, where it can lead to obstruction of blood flow and impair normal hemodynamic functions. Heart disease, ischemic stroke, pulmonary embolism, peripheral vascular disease, and many others all share a common pathophysiological process of thrombus formation.1 The applications and use of thrombolytic therapy with reperfusion of occluded vessels has a major impact on the outcome of the above diseases. Thrombolysis is a standard treatment option for acute ST-segment elevation myocardial infarction (STEMI), stroke, pulmonary embolism, and other thromboembolic diseases. In this chapter the mechanisms of thrombus formation are reviewed; the various types, mechanism of action, and the use of different thrombolytic agents as well as major cardiovascular clinical trials are highlighted.

Your Heart and Nutrition

Your Heart and Nutrition

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