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Diseases, disorders, and treatments of urogenenital tract function (that also include the kidney: see 6.25 Renal Dysfunction in Hypertension and Obesity) fall into two distinct camps, those that involve a distinct disease state, e.g., bladder dysfunction related to age, cancers of the kidney, bladder and prostrate, infections, etc. and more lifestyle-related disorders/uses, the majority related to sexual function, the most well known of which is erectile dysfunction (ED).1

Current treatment of defined urogenital disorders reflects a mixture of; surgical procedures, e.g., transurethral resection of the prostate (TURP); devices, e.g., stents, that can be inserted into the urethra to help improve urine flow; and drug therapy. The latter is growing in importance due to its inherent convenience and improved side effect profile. For instance, TURP has as a potential side effect impotence due to tissue and nerve damage resulting from the surgery.

The markets for the various disorders of the urogenenital tract that also include ED, female sexual dysfunction, and reproductive function (and dysfunction) are large and growing, especially with the aging of the population and a focus on a continued active lifestyle, both in terms of sexual function and exercise. The market for drugs acting on the urinary tract was $4.7 billion in 2003 and is anticipated to double by 2010.

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