Lanoteplase nPA

The Intravenous nPA for Treatment of Infarcting Myocardium Early (InTIME)-1 study compared a single bolus dose of lanoteplase (15-120 kU kg " 1) with an accelerated regimen of alteplase in patients and found that coronary patency at 90 min (83% versus 71%) and frequency of TIMI grade III flow were greater with the highest doses of lanoteplase compared to alteplase.71

The InTIME-1 study was followed by InTIME-2, which assessed mortality at 30 days in patients with acute myocardial infarction randomized to either nPA or t-PA.72 The 30-day and 6-month mortality was similar between the two groups. Intracranial hemorrhage was more frequent in those treated with nPA. Overall bleeding complications were equal in the two treatment groups, however, mild complications occurred more frequently in nPA-treated individuals (19.6% versus 14.7%).

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