Lipoproteina and Coronary Heart Disease Risk

While Lp(a) particles have been identified in atheroma tissue, their natural biological function is unknown.4 Lp(a) has proinflammatory and chemoattractant properties since it stimulates the expression of cell adhesion molecules. While

Lp(a) and apo(a) plasma levels vary widely throughout the general population, high Lp(a) plasma levels have been associated with an increased risk of CHD, stroke, and early MI in both middle-aged and elderly males. In these subjects, there was also a close correlation between increased plasma oxPL levels and higher Lp(a) concentrations. Although elderly females had overall higher average Lp(a) plasma concentrations than males, these females did not display an associated higher CHD risk.27,28

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