Locomotor activity

Practically all antipsychotic agents decrease spontaneous locomotor activity and decrease locomotor activity that has been pharmacologically increased by amphetamine 17, PCP 2, or apomorphine 18. As described for CAR, decreased locomotor activity can be interpreted as an in vivo readout of DA antagonism. However, the ability of nondopaminergic agents to induce hyperlocomotion that is sensitive to antipsychotics, and the ability of novel nondopaminergic compounds to reduce hyperlocomotion elicited by amphetamine suggest that this particular model involves a more complex circuit that may possibly have some relevance to the clinical state.

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