Low Density Lipoprotein Cholesterol Lowering Agents

With seven approved statins already available for patient treatment, some of which are reaching or approaching generic status, it seems unlikely that additional HMG-CoA reductase inhibitors beyond pitavastatin will be developed. However, several other approaches are currently being explored to offer patients alternatives for LDLc lowering. The recent discovery of the Niemann-Pick C1-Like1 protein as the molecular target for ezetimibe.74 should stimulate new research for second-generation cholesterol absorption inhibitors.

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