Mechanisms of action

Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative that binds to the ATP-sensitive potassium channels in the pancreatic b-cell, resulting in increased insulin secretion. Pharmacologic activity is both dose-dependent and glucose-dependent. In vitro studies using islet cells of mice showed that repaglinide causes a greater insulin secretion than glyburide in the presence of moderate glucose concentration. Conversely, glyburide caused greater insulin secretion than repaglinide at the extremes of glucose concentrations, either in the absence of glucose or in high concentrations of glucose.58 Nateglinide, a D-phenylalanine derivative, has a similar mechanism of action as repaglinide but a lower binding affinity for the sulfonylurea receptor.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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