Mechanisms of action

Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative that binds to the ATP-sensitive potassium channels in the pancreatic b-cell, resulting in increased insulin secretion. Pharmacologic activity is both dose-dependent and glucose-dependent. In vitro studies using islet cells of mice showed that repaglinide causes a greater insulin secretion than glyburide in the presence of moderate glucose concentration. Conversely, glyburide caused greater insulin secretion than repaglinide at the extremes of glucose concentrations, either in the absence of glucose or in high concentrations of glucose.58 Nateglinide, a D-phenylalanine derivative, has a similar mechanism of action as repaglinide but a lower binding affinity for the sulfonylurea receptor.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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