Metabotropic Glutamate Receptors

G protein-coupled receptors for glutamate, metabotropic glutamate receptors (mGlu), play a diverse modulatory role in neurotransmission and are potential targets for novel anxiolytic drugs.124 The eight known mGlu receptors are divided into three families, group I (mGlu15), group II (mGlu23) and group III (mGlu^^^), based on structure, pharmacology, and signal transduction. The focus for anxiolytics has been on group I and II mGlus, although data from mGlu7 and mGlu8 knockout mice suggest that group III receptors may also be relevant for altered anxiety and stress responses.

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