Mixedlineage kinase inhibitors

The c-jun JNK pathway leading to c-jun phosphorylation is involved in neuronal death in response to a wide variety of stimuli, including trophic factor withdrawal, Ab, MPTP glutamate, and NMDA toxicity. Although JNK is a target for preventing neuronal death, upstream kinases in this pathway, in particular, the MLKs are of interest.

CEP-1347 73 is an MLK inhibitor that blocks JNK signaling and has broad neuroprotective activity in a variety of in vitro and in vivo models of neuronal cell death.76 Of relevance to PD, CEP-1347 promotes survival of embryonic dopaminergic neurons77 and blocks MPP + induced cell death and MPTP-dependent increases in nigral JNK pathway activation and loss of SNpc DA neurons and striatal nerve terminals. Evaluation of CEP-1347 in a phase II/III trial for its ability to modify the course of PD showed no benefit of the NCE, and its development for PD was discontinued.75

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook

Post a comment