Mk677 GABAb receptor agonists

There has been considerable interest in the use of the g-amino-butyric acid B (GABAb) receptor agonist baclofen (59) as a potential prokinetic treatment for GERD. Baclofen reduces the occurrence of transient relaxations of the lower esophageal sphincter, reducing the reflux of acidic gastric contents.111 Another GABAB receptor agonist, APFSiA (60), has similar activity.112 In mice, baclofen administration has complex effects on gastric emptying, increasing the emptying of solids, but delaying the emptying of liquids.1 entered development for the treatment of GERD.

The GABAb receptor agonist AZD-3355 (61)114 has

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