Modulating the Renin Angiotensin System

There is compelling evidence that modulating the RAS attenuates renal disease progression through blood pressure-independent mechanisms (Figure 9). For example, the ACE inhibitor enalapril slows the progression of end-stage renal failure compared with b-adrenoceptor blockers although blood pressure control is similar in both treatment groups. These data suggest that the protective effect of enalapril on renal function was not mediated through blood pressure and it could be attributed to the blocking of AT-II-induced increase in ROS, growth factors, inflammatory cytokines, and interstitial fibrosis. Therefore, interfering with the RAS may reduce proteinuria and provide a renoprotective effect in hypertension and diabetes.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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