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Angiographic observations suggest that abciximab facilitates dissolution of intracoronary thrombi without a significant risk of distal embolization.81 Moreover, abciximab administered in conjunction with low-dose thrombolytic agents, e.g., reteplase, produces a sustained fibrinolytic effect and enhanced early reperfusion in patients with AMI with a favorable hemorrhagic profile as compared to full-dose thrombolytic therapy.82 However, larger mortality trials need to be performed to provide definitive evidence as to whether such combination therapies improve mortality without increasing the risk of intracranial hemorrhage to an unacceptable level.37

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