N

Lorazepam

Clinically, BZs are used in the treatment of panic disorder, PTSD, and GAD when rapid onset is required. Selection of the specific BZ generally depends on the desired pharmacokinetic outcome. For instance, clonazepam has a t1/2 of 20-50 h, which can be used once or twice a day. Lorazepam (t1/2 = 10-20 h) is used if drug accumulation is an issue and alprazolam offers a short half-life option (see Figure 4).

Use of the BZs has been curtailed due to potential for abuse, relapse, and significant withdrawal symptoms once treatment has ceased.86 The observation that anxiety and depression are comorbid conditions has led current therapy away from BZ therapy alone1'86 and introduced the use of drugs typically used for 'mood elevation' in anxiety disorders.

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