GABAa receptors. In mice and monkeys, RWJ-51204 showed anxiolytic effects that were separated from doses causing sedation, although in the rat, sedative and anxiolytic effects overlapped. In monkeys the anxiolytic effects of the compound showed a lower maximum compared with benzodiazepine full agonists and were similar to other partial agonist comparators. In 1999, the compound was reported to reduce CCK-4-induced panic in normal volunteers,116 but further clinical development activities have not been reported.

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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