N

GABAa receptors. In mice and monkeys, RWJ-51204 showed anxiolytic effects that were separated from doses causing sedation, although in the rat, sedative and anxiolytic effects overlapped. In monkeys the anxiolytic effects of the compound showed a lower maximum compared with benzodiazepine full agonists and were similar to other partial agonist comparators. In 1999, the compound was reported to reduce CCK-4-induced panic in normal volunteers,116 but further clinical development activities have not been reported.

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