Neuregulin (NRG1) on chr8p13 contains a core epidermal growth factor (EGF) domain and activates Erb-3 or -4 receptor tyrosine kinase.30 It is involved in migration of GABAergic interneurons, signaling between axons and Schwann cells and the interactions between NMDA receptors and PSD-95. NRG-1 knockout mice show symptoms of schizophrenia. While 17 of 21 genetic association studies showed polymorphisms in NRG-1 associated with schizophrenia, the majority lie in noncoding regions of the genome. The NRG-1 genotype has been associated with the therapeutic response to clozapine in a Finnish population. The evidence for the involvement of NRG-1 in schizophrenia is typified as 'substantial but not incontrovertible'30 and there have been studies with failure to replicate.31

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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