Neurochemical modulators exist at every level within the complex neurocircuitry described above, providing a large number of potential therapeutic targets for the treatment of anxiety. Despite the variations in clinical presentation of the various anxiety disorders, extensive preclinical studies have provided significant evidence for the role of multiple neurochemical systems in the etiology of anxiety, in general, with a significant amount of overlap between the individual disorders themselves. The major neuromodulators and neuromodulatory systems that have been implicated both through preclinical and clinical studies include the monoamines (5-hydroxytryptamine (5HT), norepinephrine (NE), and dopamine), corticotrophin-releasing factor (CRF), g-amino-butyric acid (GABA), glutamate, neuropeptides (substance P, neuropeptide Y galanin), cholecystokinin, and neurotrophic factors.20
Was this article helpful?
Stop Letting Anxiety Rule Your Life And Take Back The Control You Desire Right Now! You don't have to keep letting your anxiety disorder run your life. You can take back your inner power and change your life for the better starting today! In order to have control of a thing, you first must understand it. And that is what this handy little guide will help you do. Understand this illness for what it is. And, what it isn't.