Neurochemical modulators exist at every level within the complex neurocircuitry described above, providing a large number of potential therapeutic targets for the treatment of anxiety. Despite the variations in clinical presentation of the various anxiety disorders, extensive preclinical studies have provided significant evidence for the role of multiple neurochemical systems in the etiology of anxiety, in general, with a significant amount of overlap between the individual disorders themselves. The major neuromodulators and neuromodulatory systems that have been implicated both through preclinical and clinical studies include the monoamines (5-hydroxytryptamine (5HT), norepinephrine (NE), and dopamine), corticotrophin-releasing factor (CRF), g-amino-butyric acid (GABA), glutamate, neuropeptides (substance P, neuropeptide Y galanin), cholecystokinin, and neurotrophic factors.20
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Tips And Tricks For Relieving Anxiety... Fast Everyone feels anxious sometimes. Whether work is getting to us or we're simply having hard time managing all that we have to do, we can feel overwhelmed and worried that we might not be able to manage it all. When these feelings hit, we don't have to suffer. By taking some simple steps, you can begin to create a calmer attitude, one that not only helps you feel better, but one that allows you the chance to make better decisions about what you need to do next.