Neuroimmunophilin ligands were derived from the immunosuppressant, rapamycin (FK-506), which had potent neurotrophic properties.74 The first of these NCEs, GPI-1046 71, demonstrated a 'sprouting' effect by increasing tyrosine hydroxylase immunoreactivity in the striatum of MPTP-treated mice and reduced amphetamine-induced ispilateral rotations in unilateral 6-OHDA-lesioned rats. GPI-1046 lacked efficacy in MPTP-treated nonhuman primates. A second-generation NCE, GPI-1485, was advanced to Phase II clinical trials to investigate its potential neuroprotective effects on dopaminergic neurons but was discontinued.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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