Neurokinin3 Antagonists

Two neurokinin3 (NK3) antagonists, osanetant 76 and talnetant 77, which have selective interactions with the NK3 receptor in the range of 1 nM, have been reported to have clinical efficacy in schizophrenia.74 Osanetant had similar efficacy to haloperidol on positive symptoms with reduced EPS and weight gain liabilities. NK3 receptors present on DA neurons in the A9 and A10 groups are thought to modulate DA release, agonists increasing DA release.

Was this article helpful?

0 0
Losing Weight Natures Way

Losing Weight Natures Way

Feel Healthier And Look Better Without Resorting To Drugs! Would you like to get your hands on a this report that can teach you everything you need to know about losing weight naturally?

Get My Free Ebook


Post a comment