New Research Areas

Despite the disappointments of previous neuroprotective drug development efforts for stroke and TBI, there is still a widely held belief that it is possible to treat these acute neurological conditions. This belief is based on three accomplishments:

1. the identification of past avoidable mistakes in preclinical and clinical trials that should be avoidable in future studies

2. an improved understanding of the intricacies of previously targeted postischemic or posttraumatic secondary injury mechanisms, their time course, and interrelationships

3. the discovery of better and more therapeutically practical neuroprotective drug targets.

The following is a discussion of some of the more promising neuroprotective strategies, some of which are not all that new, and some that are relatively novel.

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