Newer Anticonvulsant Drugs

6.11.6.3.1 Rufinamide

Rufinamide (Figure 3) is an orally active GABAb receptor antagonist targeted for used as adjunct therapy for Lennox-Gastaut syndrome and for partial-onset seizures with and without secondary generalization in adults and adolescents.42

6.11.6.3.2 Becampanel

Becampanel (Figure 3) is an aminomethylquinoxalinedione AMPA receptor antagonist (IC50 = 11 nM). It is under development for the potential treatment of status epilepticus and other types of seizures. It is also being evaluated for use in the treatment of neuropathic pain and cerebrovascular ischemia.

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