Table 2 Ocular hypotensive anti-glaucoma agents

Class of agent

Mechanism of action

Inflow-inhibition agents ß-Adrenergic antagonists

Carbonic anhydrase inhibitors

(^-Adrenergic agents

Dopamine agonists

Na+-K+-ATPase inhibitors

Chloride channel inhibitors

Conventional outflow agents Muscarinic agonists

Chloride transport inhibitors Protein kinase inhibitors

Marine macrolides

Guanylate cylase activators

K-Opioid agonists


Serotonin-2 agonists

MMP activators and AP-1 activators

Uveoslceral outflow agents FP-class PGs

5HT2 agonists

Timolol maleate, Betaxolol, Levobunolol,

Metipranolol, Timolol hemihydrate Dorzolamide, Brinzolamide

Apraclonidine, Brimonidine, Clonidine

SDZ GLC-756, (S)-(-)-3-Hydroxyphenyl)-N-n-propylpiperidine (3-PPP) PD128907, CHF1035, CHF1024 Ouabain, Endothelin, Nitric oxide inhibitors

5-Nitro-2-(3-phenylpropylamino)benzoate (NPPB)

Pilocarpine, Pilocarpine, Carbachol,

Acecledine Ethacrynic acid, Indacrinone, Ticrynafen

Y-27632, Blebbistatin, Chelerythrine

Latrunculins A and B, Bumetanide Swinholide

Bremazocine, Dynorphin

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