O

6.08.3.5.3.1 Monoamine oxidase-B inhibitors

Selegiline 64 is an irreversible MAO-B inhibitor approved as adjunct therapy in PD patients being treated with L-dopa. Rasagaline (67) is a newer irreversible MAO inhibitor highly selective for MAO-B: it is 5-10 times more active than selegeline.72 It cannot be metabolized to amphetamine and thus does not produce amphetamine-like behavioral effects.

6.08.3.5.3.2 Catechol O-methyltransferase inhibitors

Inhibition of COMT prevents metabolism of L-dopa. Entacopone 65 and tolcapone 66 are COMT inhibitors approved for adjunct treatment to L-dopa in PD. Entacopone is an improvement over tolcapone in terms of liver toxicity issues.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment