Compound 57a - neuroprotection only

Figure 12 Chemical structures of the tripeptide thyrotropin-releasing hormone (TRH) and analog. TRH and the synthetic analog YM-14673 possesses endocrine, analeptic, autonomic, and neuroprotective effects. The neuroprotective effects of TRH are lost in the case of MK-771, which retains the endocrine, analeptic, and autonomic properties. In contrast, the diiodoimidazle analogs of TRH (2,4-diiodo-TRH) and YM-14673 (Compound 53a), and diketopiperazine-containing Compound 57A are selective for neuroprotective effects of TRH only.85

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