Overall Market Size and Anticipated Growth

The efficiency of eradication of H. pylori infection (around 95-98%) and the use of antibiotics have completely changed the approach to peptic ulcer therapy, significantly reducing the use of antisecretory compounds. Nonetheless, as shown in Table 1, antiulcer drugs represent the second most frequently sold drug class.

Antisecretory compounds are used for the long-term treatment of GERD, a chronic disorder of the esophagus that results a decrease of the low esophageal sphincter (LES) barrier tone, leading to acid reflux, epithelial erosion, ulceration, and, sometimes, hyperplasia accompanied by inflammation. The introduction of endoscopes and ambulatory devices for the monitoring of esophageal pH has led to an improved diagnosis of GERD and its complications. Prokinetics and antacids are also used currently, but these therapies, although effective, do not influence the underlying causes of the disease. GERD is not sensitive to the eradication of H. pylori, and is highly prevalent in the population (8-10% in USA).10 New approaches to GERD include endoscopic suturing devices to tighten the LES, endoscopic submucosal implantation of gelatinous microspheres in the lower esophagus, and radiofrequency energy delivery to the LES, but larger controlled trials with long-term follow-up are needed to establish their effective therapeutic role.

In view of the above, the interest of gastroenterologists and researchers has recently moved to diseases such as IBS, IBD, and colorectal cancer, where there is a large unmet medical need.

IBS, a dysregulation of the brain-gut axis resulting in altered gut motility and visceral sensitivity (see 6.29 Irritable Bowel Syndrome),11 is a common disorder, affecting 9-23% of the total population, with a largely idiopathic causality,

Table 1 Leading therapy classes by global pharmaceuticals sales in 2004s

Position Audited world therapy class 2004 sales ($ billions) Global sales (%) Growth (year over year) (%)

Table 1 Leading therapy classes by global pharmaceuticals sales in 2004s

Position Audited world therapy class 2004 sales ($ billions) Global sales (%) Growth (year over year) (%)

1 Cholesterol and triglyceride reducers

Herbal Remedies For Acid Reflux

Herbal Remedies For Acid Reflux

Gastroesophageal reflux disease is the medical term for what we know as acid reflux. Acid reflux occurs when the stomach releases its liquid back into the esophagus, causing inflammation and damage to the esophageal lining. The regurgitated acid most often consists of a few compoundsbr acid, bile, and pepsin.

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