Metformin (Figure 7) is absorbed via the small intestine, with 50-60% bioavailability. The maximal plasma concentration of 1-2 mg mL~ 1 occurs 1-2 h after an oral dose of metformin, with minimal binding to plasma proteins. The plasma halflife is estimated at 1.5-4.9 h. Tissue distribution is proportional to the circulating plasma concentration, with higher concentrations found in the liver and kidney. The highest concentrations are found in salivary glands and intestinal mucosa. Metformin is not metabolized in vivo and is renally cleared, with approximately 90% elimination within 12 h. Impaired glomerular filtration or tubular secretion can cause high circulating levels of metformin.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook

Post a comment