Pharmacokinetics

Thiazolidinediones are rapidly absorbed, with peak serum concentrations of rosiglitazone occurring within 1 h and pioglitazone within 2 h of oral administration. Administration with food does not prevent drug absorption, but may delay the time to peak serum concentration. Both rosiglitazone and pioglitazone are avidly protein-bound, primarily to serum albumin. The plasma half-life for rosiglitazone is 3-4 h and it is extensively metabolized. Pioglitazone has a halflife of 3-7 h and it is metabolized by hydroxylation and oxidation. The active, but less potent, metabolites have half-lives of 16-24 h.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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