Acarbose acts locally in the gastrointestinal tract on the surface of enterocytes. Only 2% of an oral acarbose dose is systemically absorbed, with a plasma half-life of 2 h. Acarbose is metabolized by the intestinal microbial flora and digestive enzymes and excreted in the stool.

Miglitol requires systemic absorption to achieve its therapeutic effect. Oral absorption is rapid and nearly complete, but saturable; nearly all of a 25-mg dose is absorbed systemically, whereas only 50-70% of a 100-mg dose is absorbed. Miglitol is not metabolized in vivo and is renally excreted. In individuals with severe renal dysfunction, plasma levels of both acarbose and miglitol may rise.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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