Pharmacokinetics

Both first-generation sulfonylureas (tolbutamide, chlorpropamide, tolazamide, and acetohexamide) and second-generation sulfonylureas (glyburide, glipizide, and glimepiride) are rapidly absorbed after oral administration. The half-lives are between 4 and 10 h with the duration of glycemic effect ranging from 6 to 24 h. The exception is chlorpropamide, which has a half-life of 25-60 h and a duration of glycemic effect of 24-72 h. Most sulfonylureas are hepatically metabolized and renally cleared. Active circulating metabolites may prolong the hypoglycemic effect, especially in individuals with acute or chronic renal impairment.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment